Simulations of Protein Aggregation
نویسندگان
چکیده
منابع مشابه
Computational simulations of the early steps of protein aggregation.
There is strong evidence that the oligomers of key proteins, formed during the early steps of aggregation, could be the primary toxic species associated with human neuro-degenerative diseases, such as Alzheimer's and prion diseases. Here, we review recent progress in the development of computational approaches in order to understand the structures, dynamics and free energy surfaces of oligomers...
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X iv :q -b io /0 60 80 41 v1 [ qbi o. B M ] 2 9 A ug 2 00 6 Scenarios for protein aggregation: Molecular Dynamics simulations and Bioinformatic Analysis Ruxandra I. Dima, Bogdan Tarus, John E. Straub and D. Thirumalai 1 Department of Chemistry, University of Cincinnati, Cincinnati, OH 45221 2 Department of Chemistry, Boston University, Boston, MA 02215, Biophysics Program, Institute for Physica...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2013
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2012.11.288